Word: ccr5
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Even more controversial are attempts to patent not whole genes like CCR5 but mere snippets, such as ESTs (expression sequence tags) and SNPs (single nucleotide polymorphisms). Incyte, for instance, aims to patent more than a million ESTs. Such patents, says American University law professor James Boyle, are "fishing expeditions"--reeling in fish they don't know what to do with...
This year Human Genome Sciences won sweeping rights to future products based on a gene known as CCR5. The protein it encodes has emerged as a promising target for anti-AIDS drugs. That rankles Christopher Broder, who, along with a platoon of other scientists, nailed down the link between CCR5 and AIDS. Why, Broder asks, should Human Genome Sciences profit from their hard work...
...course, now that we know the extent of HIV's nastiness we can get a lot closer to defeating it. The little hook that HIV uses to bind itself to cell receptor CCR5, for example, could be the virus' Achilles' heel. Blocking that hook may be the key to preventing HIV's ability to infect. "There's no question we're better off now than we were before," said Sodroski. "Before we were blind, now we are sighted." And that's a miracle in itself...
Last year, Associate Professor of Pathology Joseph G. Sodroski found two other gate proteins that HIV uses to enter cells in the rest of the body--CCR5 and CXCR4...
Gabuzda used this discovery to try to find out if any of these proteins allowed HIV into microglia. She found that CCR5, and another protein--CCR3--are part of the complex that is the brain's gate...
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