Word: cd4
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Dates: during 1990-1999
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These drugs were used by the researchers to understand the dynamics of HIV production. The researchers correlated the virus growth to the level of CD4, a type of white blood cell, and used three types of drugs to inhibit infection...
When the AIDS virus was discovered in 1984, AIDS seemed like a routine type of disease. HIV attacks a group of white blood cells, called CD4 or T4 cells, which are an essential part of the body's immune system. AIDS was thought to be direct result of this infection...
Shaw sees this work as "the first step in what needs to be a series of studies." He believes that HIV and CD4 need to be correlated at all stages of infection, new drugs must be made to combat existing and new enzyme targets, and combinations of drugs must be tested...
Shaw plans to explore the HIV and CD4 relationship at earlier stages of disease, look at cellular targets that harbor HIV and replicate with varying efficiency, and to evaluate the number of pre-existing mutants...
...virus was first isolated in 1983, scientists have been trying to determine which receptor on the surface of healthy immune cells is used by the virus to infect the cells. By blocking the receptor, researchers might be able to prevent the illness from taking hold. One such receptor, called CD4, has already been identified, and now biologists in France have reported evidence suggesting that they have found a second, CD26, which the virus must use in conjunction with the first...