Word: cd4
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
...This lack of basic rights trickles down to the children who are often under women's care. "I saw a nine-year-old girl, who had just tested HIV-positive two weeks ago," continues Kim. "I had never seen a CD4 count so low; I could not believe she was still walking without blatant evidence of infection. I tried to impress upon her father the urgency of the situation, the full import of such an immunocompromised state, the dire need for ARVS, urging him to return as soon as possible for adherence counseling with a second caregiver. His response...
When gp120 binds to CD4 receptors, which are found on the surface of HIV’s target cells, it initiates a cascade of events that alters the shape of the complex, allowing HIV to evade the antibodies of the immune system...
Another observation relevant to the newly revealed structure is that “we see a potential binding site for a small molecule,” Harrison said. There is a “deep pocket on the surface, and that pocket needs to change its shape for CD4 to bind...
...especially those who've developed resistance to existing drug courses. "This is great news, especially for HIV-positive patients," Dr. Margaret Fischl, Director of the AIDS Clinical Research Unit at the University of Miami School of Medicine, told TIME.com, "because these drugs work by blocking the virus from entering CD4 cells. Once you're infected with HIV, the virus keeps infecting new cells; it's a perpetual process of infecting healthy, uninfected cells. And these drugs represent a way to keep this from happening. It's really very exciting...
That story, in fact, has inspired trials of nearly two dozen new biotech medicines. IDEC Pharmaceuticals in San Diego, for example, has zeroed in on the interactions between CD4 T cells and APCS to make antibody drugs against lupus and RA. The company's anti-RA antibody selectively switches off T cells involved in autoimmune responses by binding the CD4 molecule on their surfaces. Amgen, of Thousand Oaks, Calif., has a drug that blocks Interleukin-1, another molecule that promotes inflammation...