Word: celles
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After three years of endless experiments on mouse cells, scientists at the Harvard Stem Cell Institute have discovered the three transcription factors out of a possible 1,100 that may provide the key to unlocking the secret to growing replacement tissues—a longtime goal of regenerative medicine...
...HSCI co-director Douglas A. Melton is the first to report successful "direct reprogramming," a technique that—as its name suggests—directly transforms one type of a fully formed adult cell into another...
...first step results in a primitive and highly versatile cell. This intermediary is then guided to mature into whatever cell type scientists want. That guiding process has proven difficult to do efficiently, especially for creating insulin-producing cells, Gearhart noted...
...contrast, the new method holds the promise of going directly from one mature cell type to another. It's like a scientist becoming a lawyer without having to go back to kindergarten and grow up again, Melton says...
...converting other kinds of cells, scientists noted that the two cell types in the mouse experiment are closely related, and it remains to be shown whether the trick can be achieved with more distant combinations. In any case, scientists would have to deliver different reprogramming signals to other kinds of cells, Melton said...