Word: celles
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...Harvard professor of cell biology and pediatrics, Mark T. Keating, and an instructor in pediatrics at the Harvard-affiliated Children’s Hospital, Felix Engel, administered two drugs to rats who had suffered induced heart attacks. One of the drugs targets p38 MAP kinase, an enzyme that prevents heart muscle cells from undergoing cellular division. The other is FGF1, a growth factor that promotes the creation of new blood vessels...
Only those rats receiving both the enzyme inhibitor and FGF1 showed significant improvements in both the proliferation of heart cells and heart function. Though the administration of only the inhibitor did result in the creation of new heart muscle cells, it did not improve cardiac function. The rats that only received the growth factor did not show as much cell proliferation as those receiving the inhibitor...
Heart muscle cells, or cardiomyocytes, “need a blood supply and oxygen to survive,” said Engel. “FGF1 did not have a great effect on cell proliferation, but we found it was providing a new blood supply. If you just inhibit p38 MAP kinase, you don’t get blood vessels...
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Reached on his cell phone last night, Haddock said he hadn’t read the report yet and couldn’t comment...