Word: celling
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Dates: during 1980-1989
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...Jarmusch's Down by Law is one of the better examples of what can be done without a real plot. His movie does have a story of sorts: two New Orleans hipsters are set up by their shifty friends, end up in a cell together and, with the help of a homicidal Italian with bad English, they escape...
...addition to its benefits, AZT can cause substantial side effects, such as severe headaches and anemia, which results from the supression of blood cell production in the bone marrow. The long-term effects of AZT are unknown...
Some viruses consist of a segment of double-stranded DNA surrounded by a protein skin. When they invade a cell, the DNA takes over the cell's genetic machinery and orders it to produce copies of the virus, which escape to infect other cells. The victim cell is often killed in the process. But the AIDS virus is a so-called retrovirus and contains single-stranded RNA. Alone, RNA lacks the ability to conquer cells, but retroviruses carry an enzyme called reverse transcriptase. When the AIDS virus invades an immune-system T cell, the enzyme enables the viral...
Scientists at Burroughs Wellcome suspected that the long-unused AZT might be what was needed to stop the AIDS virus. They discovered that when the drug enters a human cell, it is converted by a human enzyme into a "false sugar" ) that resembles, but is not identical to, the sugar used by the AIDS virus' reverse transcriptase to help build a DNA strand. If the AIDS enzyme mistakenly adds a false sugar molecule to the DNA chain, DNA synthesis is halted. So, they reasoned, further reproduction of the virus would be stopped...
...request of Burroughs Wellcome, Samuel Broder and his colleagues at NCI and other institutions tested AZT in late 1984 and early 1985 on AIDS- infected human cells in the test tube and found that it seemed to interfere with viral reproduction. Subsequently, they began testing the drug on 19 AIDS and ARC victims, and early this year reported in the British journal Lancet that the subjects had shown remarkable improvement. There was, however, at least one troublesome side effect: a reduction in their blood-cell counts. It was as a result of this early work that Burroughs Wellcome requested...