Word: celling
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...Researchers in Sawyers' lab began with a chemical that showed promise in attaching to the androgen receptor on cancer cells. Then the scientists, like composers writing variations on a theme, synthesized nearly 200 versions of the drug and screened each one on prostate-cancer cells that had been engineered to be drug-resistant. In the end, two molecules - RD162 and MDV3100 - fit the experimental criteria, binding to the receptor site without stimulating cancer-cell growth. Both chemical compounds were then tested in mice. "They caused the tumors to shrink significantly," says Sawyers...
...Unlike typical antiandrogen cancer drugs, the new compounds appeared to work by more effectively blocking the androgen receptors on the cancer-cell surface, even when the total number of receptors on the cells was high, as is the case in resistance. (Read "Vitamins Do Not Prevent Prostate Cancer, Study Finds...
...Until now, only rodents and human newborns have been known to have any significant deposits of brown fat, so called because of its abnormally high concentration of dark-colored mitochondria, the engines that sustain cell activity. The primary purpose of brown fat is to regulate body temperature: the mitochondria-packed cells are designed to burn high quantities of sugar, the body's fuel, and release that energy as heat - a mechanism that newborns, fresh from the warm confines of the womb, rely on to keep them toasty...
...charm them. In London for the G-20 meeting of leading economic powers, he met the Queen and had the British press--for whom celebrity is as appealing as garlic to a vampire--eating out of his hand. (Some of the hacks surreptitiously took pictures with their cell phones as he spoke...
...whom to ask and don't mind surprises. We stumbled randomly on Otto, owner of a guesthouse called Otto's, on our first night in town. We went to his place for dinner (fantastic fried potatoes), and when we asked for advice on local tours, he pulled out his cell phone, dialed his friend Thomas and booked us instantly on a boat excursion for the following morning. His method was efficient if mysterious. Even as we boarded the boat the next morning, we had no idea where we were going or what we would...