Word: ceruloplasmin
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Dates: during 1950-1959
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More important than whether the reaction can be used as a test is the question of why it occurs at all. On this, Biochemist Akerfeldt shed some new light. What Akerfeldt's DPP reacts to is a copper-containing enzyme, ceruloplasmin, present in the blood. It had been assumed that there must be more of this enzyme in schizophrenic than in normal blood. Not so, said Akerfeldt: the reaction measures not the amount but the activity of ceruloplasmin, and this activity depends at least to some extent on the presence of a second substance which he has not identified...
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