Word: chanock
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...overcome this obstacle, the NIH researchers-Drs. Brian Murphy, Elias Chalhub and Robert Chanock and Biologist Sandra Nusinoff-decided to beat the virus at its own flexible game. Vaccines now in use are made with a type of virus that has been killed and therefore has only limited ability to stimulate the body's immunological system. The new vaccine uses a combination of live viruses that brings about a stronger immune reaction. These active (though weakened) agents can also be grown in cultures more quickly, giving scientists a better chance of staying even with the most recent flu threat...
Robert M. Chanock of the National Institute of Allergy and Infectious Dis eases proposed an unorthodox explanation. The inherited antibody, he suggested, actually makes babies more vulnerable to the potentially fatal dis ease. First, Dr. Chanock distinguished between several kinds of antibody ("im-munoglobulins"), which immunologists label alphabetically. Only type G passes the placenta and gets into the fetal blood; the others are developed later...
...under-six-months baby, suggested Dr. Chanock, still has little or no immunoglobulin A to fight off RSV. So the virus gets to his bronchioles and lungs. There, it wreaks havoc by causing 50 or more cells to merge into giant combines. Oxygen exchange is so impaired that the baby has asthma-like spasms. To make matters worse, said Dr. Chanock, the G antibody circulating in the blood just below the lungs' surface actually combines with virus particles to form more damaging complexes...
Although some virologists differed with Dr. Chanock about details, they agreed that the newly developed vaccine against RSV must not be given to infants under six months, as it appears to increase the risk and severity of pneumonia. A similar phenomenon is now being seen in connection with another viral disease: circulating antibody from killed-virus vaccine against measles also seems to make a child more susceptible to severe disease if he later receives live-virus vaccine...
...Newport dowager. Groucho, who has never seen Mrs. Dukes-bury before, barges into her boudoir, woos her with this Marxian dialectric: "Those June nights on the Riviera . . . and that night I drank champagne from your slipper -two quarts." The big scene is the party for the 400. "Judge Chanock," says Mrs. Dukesbury graciously, "will sit on my left hand, you (to Groucho) will sit on my right hand." "How will you eat," cracks Groucho, "through a tube...
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