Word: chip
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MICHAEL EISNER Weaker Disney nets CEO half 1997's $9.9 mil bonus. Mickey gets Velveeta. Chip eats Dale...
Students who receive a higher aid package from one school than another can use the higher offer as a bargaining chip, threatening to attend the more generous school...
...oncologist takes a few cells from Jose's tumor and places them on a microchip. Within minutes, the chip identifies five mutant genes that, like some kind of diabolical cheerleading squad, have pushed Jose's cancer to grow, grow, grow. Someday, perhaps soon, doctors will be able to fix the wayward genes themselves. Until then, they will have to rely on the next best thing: drugs developed by pharmaceutical firms that block the destructive messages generated by the errant genes. Jose's physician selects a combination of treatments that matches the tumor's genetic profile. Six months later, no trace...
...would you make a gene chip? Let's say you want to identify which genes get turned on, or "expressed," by the immune system in the first few weeks after the AIDS virus begins its attack on the body. First you download the sequences of perhaps 10,000 genes--every A, C, G and T of the hereditary alphabet--into a computer. Then, still using the computer, you figure out what the mirror image of each sequence would be. (DNA can mirror itself as well as RNA.) The aim is to transform the mirror-sequence data into actual strands...
Once the strands are complete, the gene chip is ready for use. You take a sample of blood from a patient who has just developed a raging HIV infection. Various genes in his immune system are churning out millions of RNA molecules that will assemble the proteins needed to combat the infection. You extract the RNA and break it into pieces, tag each piece with a fluorescent chemical and pour the whole mess over the gene chip. The RNA tightly binds only to its exact DNA complement on the chip. The fluorescent tag tells you where on the chip...