Word: chloramphenicol
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Dates: during 1970-1979
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...connection, I would question the specification, in the Guidelines that an EK2 strain must have a survival frequency of less than 10-8 under natural conditions (interpreted by the committee as residual viability after 24 hours). Just as infection can be dramatically cured by a bacteriostatic antibiotic, such as chloramphenicol, as well as by a bactericidal one, such as penicillin, so the inability of an EK2 strain to multiply in the gut would be sufficient to ensure its rapid disappearance, even if it did not rapidly commit suicide. The important question, requiring extensive investigation, is not the rate of suicide...
...applied directly to the skin to deal with acne pustules. In tests, they treated 80 youngsters with moderate acne with four widely used antibiotics, applying the medications twice daily for eight weeks and counting the number of lesions at the end of each month. Three of the drugs-chloramphenicol, isoniazid and tetracycline-proved of little value. The fourth, erythromycin, showed that it may be worth further study. After four weeks, the drug had produced a small, but measurable reduction in acne lesions on the foreheads and cheeks of 16 of the 20 patients using...