Word: chloramphenicol
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...connection, I would question the specification, in the Guidelines that an EK2 strain must have a survival frequency of less than 10-8 under natural conditions (interpreted by the committee as residual viability after 24 hours). Just as infection can be dramatically cured by a bacteriostatic antibiotic, such as chloramphenicol, as well as by a bactericidal one, such as penicillin, so the inability of an EK2 strain to multiply in the gut would be sufficient to ensure its rapid disappearance, even if it did not rapidly commit suicide. The important question, requiring extensive investigation, is not the rate of suicide...
...applied directly to the skin to deal with acne pustules. In tests, they treated 80 youngsters with moderate acne with four widely used antibiotics, applying the medications twice daily for eight weeks and counting the number of lesions at the end of each month. Three of the drugs-chloramphenicol, isoniazid and tetracycline-proved of little value. The fourth, erythromycin, showed that it may be worth further study. After four weeks, the drug had produced a small, but measurable reduction in acne lesions on the foreheads and cheeks of 16 of the 20 patients using...
...Marine Medicine and Pharmacology. In speech after speech they pointed out that the vast majority of all known forms of animal life are found in the sea, which they expect to yield a proportionately rich harvest of medically useful chemicals. Dr. Paul R. Burkholder, famed for his discovery of chloramphenicol* (in a Venezuelan soil mold) more than 20 years ago, prodded the pharmaceutical industry to speed up its testing of sea-spawned compounds that show antibiotic promise, a number of which he himself has isolated...
Although spotted fever may prove fatal if not treated promptly, it can almost always be cured with antibiotics (chloramphenicol or the tetracyclines) if diagnosed early enough. The trouble, say Murray and his colleagues in the New England Journal of Medicine, is that most doctors in the East are not alert to the danger. Unless they happen to spot the palms-and-soles rash, they are likely to misdiagnose the disease and treat it with sulfas or penicillin-both of which seem to make it worse. Lives can be saved, they say, if doctors will look for the distinctive signs, especially...
There is no doubt that chloramphenicol, better known by Parke, Davis & Co.'s trade name of Chloromycetin, is a potent and valuable antibiotic. That has been clear since 1947, when it was found to kill a wider variety of bacteria than penicillin or other early antibiotics. Better yet, it was one of the first drugs to show activity against some odd ball microbes called rickettsiae. But Chloromycetin soon showed another side of its character: a few patients developed a severe anemia after taking it, and by 1952 it was clear that some of these patients had died...