Word: chloramphenicol
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...antibiotic is good, two must be better, and three even more efficacious." Not so, the Wehrle team found. In a twelve-month study at Los Angeles County General Hospital, every meningitis patient got intravenous ampicillin, a fast-acting form of penicillin, while alternate patients received, in addition, chloramphenicol and streptomycin. There were five deaths among 129 patients on ampicillin alone, but 13 among the 111 who got all three drugs. Using an antibiotic combination is evidently detrimental, perhaps because it interferes with the action of ampicillin...
When it is administered, preventive vaccine is effective, but fresh batches must be kept under refrigeration and administered within two weeks before they go stale-a schedule that is all too easily missed in the war-weary countryside. Massive doses of antibiotics such as streptomycin and chloramphenicol often save those stricken with plague, but without early diagnosis and treatment, the chance of recovery is slim...
...Chloramphenicol (Chloromycetin), though one of the most dangerous drugs in wide use, is by far the best for typhoid fever. In the Philippines, among 408 charity patients suffering from typhoid, chloramphenicol was deliberately withheld from 157, of whom 36 died. Only 20 died among the 251 who got the standard treatment. By statistical deduction, 23 patients died needlessly for the sake of the study...
...CHLORAMPHENICOL. For 15 years FDA has struggled with the problem of how to label and whether to restrict the use of this antibiotic (Parke, Davis' Chloromycetin). It is unquestionably the best drug against half a dozen uncommon diseases and a few medical conditions that should be treated in hospitals. But it is often prescribed to avert the aftereffects of a common cold, for which it is useless and also dangerous, because it may cause death from anemia...
...with food handling. But grandma takes over in the kitchen. If she is careless about bathroom cleanliness (the bacilli are transmitted from fecal matter only through food and drink), she gives the youngsters an unwelcome and unexpected gift of typhoid. Their acute illnesses can be cured with chloramphenicol (Chloromycetin). After this modern treatment so few become carriers, they create a negligible problem for the future. But grandma's long-standing carrier condition requires intensive and difficult treatment, which most of the elderly women refuse. It will take another generation. Dr. Smadel suggested, for typhoid...