Word: chloromycetin
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There were plenty of individual exceptions to the general rise. Price-cutting in the "wonder drugs" and heavy criticism of Chloromycetin drove Parke Davis' net down 57% (to $2,200,000), and further inroads on coal's markets by oil and gas drove Pittsburgh Consolidation's net down...
...wartime scale, beginning at once, so that gamma globulin (TIME, Nov. 3) can be processed in readiness for next year's polio epidemics. The goal: 5,000,000 pints ¶Doctors of the Food & Drug Administration, spurred by last summer's scare about Chloromycetin, checked 539 cases of blood disorders, such as aplastic anemia, which might have been caused by drugs. In. 55, they found, Chloromycetin was used alone, and in 143 with other drugs, but in 341 cases other drugs or no drugs had been used. Their conclusion: doctors should watch more carefully for ill effects...
...antagonism between the drugs as there are of cooperation. By & large, they report, any two of four antibiotics in Group I-penicillin, streptomycin, bacitracin and neomycin-work well together. Except in rare cases, however, none of these four should be used with an antibiotic from Group II: aureomycin, Chloromycetin, terramycin. And while no great harm may come of combining two antibiotics within Group II, no real advantage can be expected either; the combination simply works like a bigger dose of either drug alone...
Even a single antibiotic can produce harmful (sometimes fatal) results if the doctor using it is not extremely alert. This was the case with Chloromycetin. The surest cure for typhoid fever, and one of the best drugs for Rocky Mountain spotted fever, brucellosis (undulant fever), typhus and some kinds of pneumonia, it had been given to about 8,000,000 patients since it was first marketed in 1949. Then it was found (TIME, July 14) that some patients who had been getting the drug had died of aplastic anemia (in which the bone marrow is unable to do its normal...
After a quick and thorough check by topnotch authorities, the Food & Drug Administration gave its verdict last week. Chloromycetin was connected with the deaths of at least 72 aplastic anemia victims. However, there are "serious and sometimes fatal diseases in which its use is necessary," the FDA decided; therefore, doctors may still use it. But the manufacturers, Parke, Davis & Co., must warn doctors on the leaflet packed with every bottle that studies of the patient's blood are essential if Chloromycetin is given for a long time. Further. "Chloromycetin should not be used indiscriminately or for minor infections...