Word: cholecystokinin
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...might expect, the short-term signals are involved mostly with the initiation and completion of meals. Ghrelin, a hormone produced by the stomach, tells the brain, "It's time to eat!" When enough food leaves the stomach and reaches the small intestine, another hormone, called cholecystokinin, signals that the meal is over--and triggers the release of enzymes in the gallbladder and the pancreas...
...eating side, researchers at Glaxo are studying cholecystokinin, which is released by the intestines after a meal to signal the brain that the body has had enough. Giving obese patients a synthetic form of cholecystokinin before meals tricks the body into feeling full, so patients eat less. About 25% of the participants in an early trial lost almost 7 lbs. in the first eight weeks...
...with lab animals. Using the radioimmunoassay techniques for which she won her prize, she and a co-worker at The Bronx, N.Y., Veterans Administration Hospital found a possible link between obesity and the shortage of a brain chemical. Grossly fat mice seem to have smaller amounts of the hormone cholecystokinin than their skinner littermates. In other words, the hormone may be suppressing rodent appetites. Tentative though those findings were, Yalow discussed them with the press. She had been uncomfortable ever since...
Among common drugs administered to make the gall bladder evacuate the bile are calomel (mercurous chloride), rhubarb, mandrake, jalap. New are the hormones secretin and cholecystokinin...
...bladder is a greenish globule one-twelfth of an inch in diameter (visible as a disk about the size of the fish's eye but not so dark-see cut}. Dr. Viehoever found that soon after he injected the most trifling amount of the hormones secretin and cholecystokinin into the fish's tail, the gall bladder contracted, and squeezed its green bile into the intestines. This is what human gall bladders normally do during digestion, what they cannot do when obstructed by gallstones or mucus plugs...
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