Word: cholesterol
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Dates: during 1930-1939
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...three drops of blood are taken from a finger or an ear lobe and centrifuged to remove all red blood cells. Then the clear serum is mixed with several drops of the antigen, a witches' brew of benzoin (a resin from Java or Sumatra), cholesterol (alcohol which occurs in bile), scarlet red (a dye), plain salt water, and alcoholic beefheart extract. If syphilis antibodies are present in the blood, coarse particles develop in the colorless fluid, and clumps of red granules appear around the edges of the mixture. Since the reaction is clearly visible to the naked...
...from medical school at the age of 22, Dr. Alfred Steiner of New York City's Department of Hospitals has been interested in atherosclerosis. Last week young Dr. Steiner told how he had cured rabbits of this disease. First he produced atherosclerosis in ten rabbits by feeding them cholesterol (a pearly substance found in all animal fats). He then mixed small amounts of diluted choline, a ptomaine, with the rabbits' carrots. Result: after two months six of the rabbits were cured of their lesions. After further animal work Dr. Steiner, who also teaches in Columbia's topflight...
Nicknamed "EAP" (epi-allo-pregnanolone), the hormone was extracted from pregnancy urine, one-third of an ounce from 10,000 gallons. After its structure was determined, it was easily synthesized from cholesterol, parent substance of other sex hormones. EAP differs from progesterone, a female hormone, only in having four fewer hydrogen atoms. It was administered to a man who had been impotent all his life. After ten days he became potent, and his "condition of ecstasy" lasted three days...
Last week the first synthetic production of theelin was announced in the American Chemical Society's Journal by Dr. Russell E. Marker and his associate, Thomas S. Oakwood, of Pennsylvania State College. From yeast Researchers Marker & Oakwood obtained ergosterol, an organic compound related to Vitamin D-producing cholesterol. From an ergosterol derivative, which they acetylated, oxidized with chromic acid, hydrolized and distilled, they built up the white crystals of theelin...
...announced that his assistants in his Zurich laboratory had just cabled him word of their success. Testosterone is the name of the new hormone. It is related to the male sex hormone, androsterone, found in urine which Dr. Ruzicka previously synthesized. Like androsterone, testosterone is made from the fat (cholesterol) in sheep's wool, but is 25 to 50 times as potent a masculinizer as concentrated androsterone...