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...Kitahata studied more than 17,000 HIV-positive patients who were being treated by physicians from 22 different research groups in 60 cities in North America between 1996 and 2005. She and her team essentially conducted two trials. In one, the scientists looked at patients who chose to initiate ART when their level of CD4 cells - infection-fighting immune cells that HIV uses to replicate and then systematically destroys - ranged between 351 and 500 cells per cubic mm of blood. These patients were compared with those who decided to defer therapy until their counts dipped below 350 cells per cubic...

Author: /time Magazine | Title: Study: Treatment for HIV Should Start Earlier | 4/2/2009 | See Source »

...second study, Kitahata's team looked at patients who chose to start ART when their CD4 count was 500 or above and compared them with patients who decided to defer treatment until their CD4 counts dropped below 500 cells. (In a normal, healthy adult, CD4 levels range from 600 to 1,200.) In both studies, the patients deferring treatment were more likely to have died by the 2005 end of the study than were their earlier-treated cohorts. HIV-positive patients beginning therapy at CD4 levels between 351 and 500 cells were 69% more likely to be alive...

Author: /time Magazine | Title: Study: Treatment for HIV Should Start Earlier | 4/2/2009 | See Source »

...randomized controlled trial. And as convincing and as large as the current study is, Fauci notes that it too lacks this scientific imprimatur. In Kitahata's study, researchers followed patients as they and their doctors made their own decisions about when they would begin drug therapy. Those who chose to start early - before their CD4 counts reached 350 cells or 500 cells, for instance - may have simply been more health-conscious overall and therefore less likely to die, which could have confounded the study's results. Only a randomized and controlled trial in which patients are arbitrarily assigned either...

Author: /time Magazine | Title: Study: Treatment for HIV Should Start Earlier | 4/2/2009 | See Source »

Instead of returning for a third tour, Andersson chose recruiting. He trained at Fort Jackson, filed for divorce and joined the Houston battalion in 2005. "They were working the crap out of him," Robert says. "I'd get calls from him at 9:30 at night - 11:30 in Houston - and he'd say he was just leaving the recruiting office and starting on his 40-minute drive home." His easygoing son also developed a hair-trigger temper during his time at the River Oaks and Rosenberg recruiting stations. "He wasn't really a salesman," Robert says, "and recruiters...

Author: /time Magazine | Title: Why Are Army Recruiters Killing Themselves? | 4/2/2009 | See Source »

OpenSkies is named after the deregulatory policy that frees airlines to add new city-to-city routes beyond their once protected home turf. OpenSkies chose Amsterdam and bought another business-class fledgling, L'Avion, to gain access to Paris and slots at Orly and share costs and culture. BA doesn't fly to those places from New York City, and it sure as heck isn't going to undercut its own lucrative business-class traffic to London...

Author: /time Magazine | Title: Open Skies Tries to Get Lift | 4/2/2009 | See Source »

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