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Medical student Yung-Kang Chow, working with a team of researchers in the lab of Dr. Martin S. Hirsch at the Massachusetts General Hospital, announced in February that a combination of AZT, ddl and one of two experimental drugs had been found to block the spread of the HIV virus to other cells in the test tube before the virus could develop sufficient resistance to the drugs...

Author: By Marion B. Gammill, | Title: AIDS Therapy May Not Work | 7/23/1993 | See Source »

...much-publicized results seemed to bear out Chow's theory that a combination of anti-HIV drugs would cause the virus to mutate to a non-reproductive form, and 400 human volunteers were selected for studies of the so-called "triple drug therapy." But other scientific teams were unable to replicate the results, prompting the Harvard team to repeat the experiment, The New York Times reported...

Author: By Marion B. Gammill, | Title: AIDS Therapy May Not Work | 7/23/1993 | See Source »

...biggest headline grabber, however, which eventually led to so much publicity that the MGH News Office placed a general blackout on further interviews with laboratory personnel, involved a triple therapy designed by fourth-year M.D.-Ph.D. student Yung-Kang Chow that had successfully knocked out HIV-1, the most common virus which causes AIDS...

Author: By Ivan Oransky, | Title: Elusive Genes Discovered | 6/10/1993 | See Source »

...Chow found that when he combined AZT and ddl, two common anti-AIDS drugs approved by the FDA, with Pyrodine, which inhibits DNA duplication by HIV-1, the virus could no longer replicate to infect other cells...

Author: By Ivan Oransky, | Title: Elusive Genes Discovered | 6/10/1993 | See Source »

After a general media blitz, followed by hundreds of calls to MGH by AIDS sufferers requesting trials of the new drug therapy, however, Chow and others scrambled to strongly caution AIDS sufferers that the discovery was only a first step toward a cure for the deadly disease...

Author: By Ivan Oransky, | Title: Elusive Genes Discovered | 6/10/1993 | See Source »

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