Word: cinchophen
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...mere demonstrations in force. Standard treatment, besides wrapping the throbbing foot in cotton wool, is a diet with plenty of water, and strangely enough, fat, especially fresh butter. Many doctors also rely on injections of colchicine (from the root of the autumn crocus) to relieve the agonizing pain, and cinchophen (a complicated synthetic acid) to promote uric acid elimination...
...Cinchophen is a bitter white powder discovered in 1887 and used since 1908 as a treatment for gout, arthritis, rheumatic fever, neuralgia, neuritis, sciatica. By 1932 U. S. invalids were annually using 90,000 Ib. of cinchophen and its derivatives...
...many U. S. doctors felt sure that cinchophen was primarily responsible for many deaths directly due to yellow atrophy of the liver. This matter was thrashed out last May during the convention of the American Medical Association. There Drs. Walter Lincoln Palmer and Paul Silas Woodall presented conclusive evidence that, although cinchophen does not poison all users, there is no way of telling whose liver it may attack or when it begins its deadly work. Said their report, released last week: "The very earliest symptoms may be only a signal, already too late, that the steady march of death...
...Cinchophen. To stimulate the excretion of uric acid and thus to remedy certain states of gout, arthritis, rheumatism, sciatica and neuralgia, doctors recently adopted a synthetic drug called cinchophen, made from quinine and carbolic acid. Soon cinchophen users complained of jaundice. Many died, and, upon autopsy, revealed extensive degeneration of the liver. Doctors nevertheless hesitated to abandon this highly useful drug...
Last week Drs. Walter Lincoln Palmer, 39, of Chicago, & Paul Silas Woodall, 27, of Montreal, said that cinchophen must go into the medical discard. Their reasons: "Very small doses given for very brief periods of time may prove fatal. Discontinuance of the drug upon the appearance of even the slightest symptoms does not ensure a favorable outcome. The first symptom usually recognized is jaundice, and withdrawal of the drug at this stage even with appropriate therapy does not prevent a fatal termination in approximately half of the cases...
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