Word: cinchophen
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Dates: during 1935-1935
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...Cinchophen. To stimulate the excretion of uric acid and thus to remedy certain states of gout, arthritis, rheumatism, sciatica and neuralgia, doctors recently adopted a synthetic drug called cinchophen, made from quinine and carbolic acid. Soon cinchophen users complained of jaundice. Many died, and, upon autopsy, revealed extensive degeneration of the liver. Doctors nevertheless hesitated to abandon this highly useful drug...
Last week Drs. Walter Lincoln Palmer, 39, of Chicago, & Paul Silas Woodall, 27, of Montreal, said that cinchophen must go into the medical discard. Their reasons: "Very small doses given for very brief periods of time may prove fatal. Discontinuance of the drug upon the appearance of even the slightest symptoms does not ensure a favorable outcome. The first symptom usually recognized is jaundice, and withdrawal of the drug at this stage even with appropriate therapy does not prevent a fatal termination in approximately half of the cases...
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