Word: claphamã
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First discovered by Clapham??€™s lab in 2001, the CatSper protein is activated by the higher pH environment of the female cervix. Activated CatSper allow calcium ions to flow into the sperm’s tail. The calcium influx, measurable as an electrical current, alters the way the flagella bends and hyper-activates the tail’s motor proteins. In experiments, mice altered to lack the CatSper protein had weak swimming sperm and were infertile...
...Clapham??€™s group discovered that CatSper is found only in the part of the sperm cell that connects to the sperm’s tail, or flagellum. This part contains the molecular machinery that allows the sperm to wave the flagellum and move forward...
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