Word: clot
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While such therapies remain theoretical, reducing stickiness is already proving useful in heart disease, specifically in combatting a dangerous side effect of clot-busting drugs like streptokinase or TPA. Doctors have found that after such drugs are used, lingering pieces of broken-up clots (consisting mainly of platelets) look to surveillance cells like a flood of damaged tissue. Instantly, the inflammation process kicks in: the affected region of the heart becomes sticky and therefore prone to further clotting. Adhesion research has produced a drug now being tested on heart patients that keeps the scattering clot fragments from sticking...
...research project, scheduled to begin in April, will focus on two major aspects of blood clot formations that often lead to strokes: genetic regulation and the mechanism of the clot formation, the statement said...
...doctors are not recommending that anyone go out and gulp aspirin for good health. The drug can have unpleasant and even dangerous side effects, including ringing in the ears and blurred vision, as well as stomach bleeding. A more serious problem is hemorrhagic stroke, caused not by a clot blocking the brain's blood vessels but by vessels that rupture. Moreover, prostaglandins appear to work in opposing pairs. The ones that promote clot formation, for example, are countered by partners that do the opposite. Too much aspirin can therefore cause the very problems that lower doses relieve...
Previous studies have shown that aspirin can reduce the risk of heart attacks by interfering with the clotting of blood. Most heart attacks occur when blood vessels are narrowed and there is difficulty with blood flow. A blood clot may then develop in the vessel and block...
...heart drug hit the market in 1987 in a blinding flash of pitchmen, promotion and public relations hoo-ha. The product of biotech breakthroughs, TPA was touted as clearly superior to the competition, a clot-busting drug called streptokinase, on the market for 15 years. Though TPA (for tissue plasminogen activator) is 10 times as expensive as the older drug, the majority of U.S. doctors bought the pitch, and the new drug became the favored method of breaking up clots in heart-attack victims. Then last week an international team of researchers reported what some doctors had suspected all along...