Word: clots
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Dates: during 1980-1989
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Ischemia occurs when coronary arteries partly clogged with fatty deposits of plaque suddenly contract in spasms or are blocked by a clot, depriving the heart muscle of blood and thus oxygen. While painful or "noisy" ischemia (angina) often results from physical stress, like climbing stairs, even slight exertions, like balancing a checkbook, can trigger silent ischemia. During these episodes, which typically last a few minutes but can go on for ten hours, large portions of heart muscle can be damaged. Yet in more than 75% of all cases, for still unknown reasons, the victim feels no pain...
...were initially afraid that this dose of TPA wouldn't do the job, because a clot that goes to the pulmonary arteries is much bigger [than one in the arteries of the heart,]" Goldhaber said...
Although it worked effectively on most lung-clot victims, TPA also caused serious internal bleeding in six percent of the patients. Goldhaber said that more, larger-scale trials would be necessary before the Food and Drug Administration would consider approving the drug for widespread...
...Another clot-dissolving drug, Urokinase, was approved by the Food and Drug Administration for experimental use in pulmonary embolism victims in 1977, but TPA seems to work more effectively, Goldhaber said...
...while the ability to destroy lethal blood clots may increase the chances of survival in some patients, it may have little or no effect in others. In many instances of heart attack, the coronary artery is not obstructed by a blood clot but by a fatty deposit known as a plaque. Since plaques are not susceptible to drugs like t-PA, other methods must be used to unblock the artery...