Word: clots
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Dates: during 1990-1999
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Temujin was born clutching a blood clot the size of a knucklebone. His name was war booty, taken from a captive rival by his proud warrior father and tacked on like a medal to his firstborn son. But history echoes with another of his names, a title Temujin would receive 39 years later. In 1206, by acclamation of all the Mongols, he became Genghis Khan, the "Oceanic Ruler" who in the next two decades would father an empire that rolled across Eurasia, linking the Pacific Ocean to the Blade Sea as it amassed kingdoms as loot and nations as slaves...
DEPRIVED HEARTS If you're 65 or older and have a heart attack, you may not get care fast enough--or at all. Researchers report that about half of elderly heart-attack patients receive neither angioplasty--where blocked arteries are Roto-Rootered open--nor clot-dissolving drugs within six hours of arriving at the hospital. The upshot: they are twice as likely to die within a year compared with those who are treated quickly...
Strokes afflict 600,000 Americans each year. In 80% of cases the culprit is some kind of clot that obstructs the flow of blood through an artery. But for a variety of reasons, blood-starved brain cells don't die right away. If the offending clot is broken up quickly enough, normal blood flow is restored and the brain is spared...
...reason the drug works so well is that doctors inject it into a catheter, which they thread through the arteries of the brain to deliver treatment directly to the site of the clot. So far, the therapy has been tested only on clots in the middle cerebral artery, which is the site of perhaps a third of clot-caused strokes. It's conceivable, Furlan says, that as many as half of such strokes can be treated in this...
Whereas traditional drug companies focus on developing chemical compounds, the biotech industry prefers to use biological ones--hormones, proteins and other substances that either already exist in the body or can be created from scratch. Examples include interferon, the clot buster tPA and the new breast-cancer drug Herceptin...