Word: clotting
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...perhaps within a year or so. Says Robert Kupor, an industry analyst with the Seattle-based Cable, Howse & Ragen brokerage firm: "It's great stuff, and there's no doubt it will ultimately be approved." Once that happens, experts expect to see a $1 billion-a-year market for clot-dissolving drugs...
Ischemia occurs when coronary arteries partly clogged with fatty deposits of plaque suddenly contract in spasms or are blocked by a clot, depriving the heart muscle of blood and thus oxygen. While painful or "noisy" ischemia (angina) often results from physical stress, like climbing stairs, even slight exertions, like balancing a checkbook, can trigger silent ischemia. During these episodes, which typically last a few minutes but can go on for ten hours, large portions of heart muscle can be damaged. Yet in more than 75% of all cases, for still unknown reasons, the victim feels no pain...
...were initially afraid that this dose of TPA wouldn't do the job, because a clot that goes to the pulmonary arteries is much bigger [than one in the arteries of the heart,]" Goldhaber said...
Although it worked effectively on most lung-clot victims, TPA also caused serious internal bleeding in six percent of the patients. Goldhaber said that more, larger-scale trials would be necessary before the Food and Drug Administration would consider approving the drug for widespread...
...Another clot-dissolving drug, Urokinase, was approved by the Food and Drug Administration for experimental use in pulmonary embolism victims in 1977, but TPA seems to work more effectively, Goldhaber said...