Word: clozaril
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
Finally, Larson says, she was given a medicine called Clozaril that "restored [her] mind and intellect," allowing her to become the editor of Spare Change...
...drugs for schizophrenia, one of the most perplexing and devastating of all mental illnesses, was an early success story. After several decades as a hopeless research backwater, the schizophrenia field was reborn in 1989, when the U.S. Food and Drug Administration approved a remarkable drug, clozapine (brand name: Clozaril). Made by the Swiss pharmaceutical firm Sandoz, Clozaril was aimed at patients who did not benefit from other drugs. While traditional antipsychotic drugs such as chlorpromazine (Thorazine) and haloperidol (Haldol) work by blocking dopamine receptors, Clozaril appears to bind to serotonin receptors as well. "It is what we call a dirty...
...scientists are exploring an entire spectrum of what Dr. Steven Paul, vice president for central-nervous-system research at Eli Lilly, calls "Clozaril wannabes" that they hope will work as well without triggering agranulocytosis. One of the wannabes, risperidone (Risperdal), made by Belgium-based Janssen Pharmaceutica, entered the market in 1993, and four others are nearing approval by the fda, including Lilly's Zyprexa and Abbott Labs' Serlect. Meanwhile, further down the drug-development pipeline are a number of third-generation Clozaril cousins, some of which are specifically targeted at the little-known D3 and D4 receptors...
...curing schizophrenia with these new antipsychotics," says Paul. "But we can treat it better. What would happen if we designed a drug that was 10 times better than Clozaril?" Mount Sinai's Davis, on the other hand, thinks future schizophrenia drugs might well be based on altogether different chemical-messenger systems. "There is evidence that schizophrenics have abnormalities in two very common neurotransmitters, gaba [gamma-aminobutyric acid] and glutamate," he says. "None of the current drugs do anything for the most incapacitating symptom of schizophrenia, the cognitive deficits. Maybe it's time to get off the dopamine merry-go-round...
Moss, Buchberger, Fitch and their fellow promgoers were awakened from their long nightmare of insanity by a remarkable drug called clozapine (brand name: Clozaril). The dinner dance, organized with help from psychiatrists and counselors at Case Western Reserve's affiliated University Hospitals, in Cleveland, served as a bittersweet celebration of shared loss and regained hope. "Those of us who are ill travel on a different road," said prom chairman Fitch in a welcoming address to his fellow refugees from madness. "We would have liked to have gone to our senior proms, but fate didn't give us that chance...