Word: colestipol
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Dates: during 1990-1999
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...controlled study demonstrating that the same results could be produced in humans. His subjects were 188 nonsmoking males who had undergone bypass surgery. (Most heart-disease research has been done on men rather than women.) Blankenhorn placed half of them on a diet containing 22% fat and gave them colestipol and large doses of niacin, both standard cholesterol-reducing drugs. The other recruits, the control group, merely limited the fat content of their diet...
Brown's study, begun in 1984 and reported at an American Heart Association meeting last year, involved 146 men with high cholesterol levels and a family history of heart disease. Brown divided his subjects into three groups, one taking niacin and colestipol, the second receiving colestipol and another cholesterol reducer, lovastatin. The third or control group got only a pair of placebos. All the men were placed on a diet that limited fats to 30% of total calories, the level recommended by the A.H.A. Here, too, after 2 1/2 years, those taking the drugs experienced large drops in their total...
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