Word: coli
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Dates: during 1970-1979
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...important step in this direction had already been taken last spring when scientists at the University of California in San Francisco succeeded in transplanting a rat insulin gene into the DNA of a laboratory strain of the bacterium Escherichia coli. The bug then multiplied into countless duplicate bacteria, each containing the insulin gene, but incapable of producing insulin. In the work announced last week, Microbiologist Herbert Boyer of the University of California, San Francisco, along with Biochemist Arthur Riggs of the City of Hope Medical Center near Los Angeles and Physiologist Wylie Vale of the Salk Institute in San Diego...
...thesis should be a learning expeience," says Irene Rosenberg '78, who is studying the structure of DNA taken from corn chloroplast into E. coli bacteria. She hopes to learn about lab techniques, and in the process, contribute information that may someday lead to benefits such as higher crop yields. "My project isn't earth-shattering, it's not cornshattering, either," she says, "but it will provide some information...
...molecule of life, might accidentally lead to the creation of new, uncontrollable strains of disease-carrying bacteria. Now most experts have decided they greatly overstated the dangers. But many laymen have remained frightened ever since research at Harvard designed to create new combinations of DNA in the bacterium Escherichia coli K12, or E. coli for short, stirred passionate debate last year (TIME cover, April 18). Last week, after long hearings, Congress was scheduled to act on two bills seeking to control such research. The rush to adjourn forced a postponement of action until after the summer recess, but the issue...
Experiments with the lowly E. coli bacterium hold a promise of many marvels, including food crops that require little fertilizer and the production of new tools for the understanding of disease, perhaps including cancer. Pursuing such research, biologists are naturally loath to become ensnared in more Government regulations. They point out that governmental regulation poses inherent dangers to the freedom of inquiry that science requires. Comments Biochemist Robert White of the National Academy of Sciences: "I hate to see the camel's nose under the tent...
...most important reason that most geneticists and molecular biologists now oppose the legislation is a growing conviction, based on continued experiments, that current recombinant DNA research is safe. Some strains of E. coli normally reside in billions in the human intestine, a fact that encouraged the fear that new laboratory forms would spread like the plague among human beings. But research has shown that E. coli K12, which traces its ancestry to bacteria taken from a human patient at Stanford University in 1922, altered genetically during its life in the labs; among other changes, it can no longer colonize...