Word: colis
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With a little help from E. coli...
...first stage of the experiment, NIH'S Malcolm Martin and Wallace Rowe will splice DNA from the polyoma virus (which causes tumors in mice but not in humans) into a specially engineered strain of the common bacteria Escherichia coli. The bacteria will be fed to or injected into mice and hamsters, which will then be examined to determine 1) if the bacteria multiply into progeny that also contain the viral DNA, and 2) if the bacteria-carried viral DNA can cause tumors in the animals...
...pass through a steam sterilizer and a disinfectant bath; the very air in the boxes will flow through an incinerator before it is vented outside. Even if an altered organism escapes, it should pose no threat. All P-4 experiments must be conducted with a weakened strain of E. coli that cannot survive outside the special conditions...
Those benefits were dramatically demonstrated last fall when California scientists inserted into the DNA of E. coli bacteria synthesized copies of a gene that orders the production of somatostatin, a vital brain hormone in mammals. Researchers who first isolated that hormone needed nearly half a million sheep brains to produce 5 mg (.00018 oz.) of the substance. But the California scientists used only about 8 liters (2 gal.) of a culture containing their re-engineered bacteria to obtain the same amount...
Fink said that he and two assistants have been able to isolate complex DNA containing genes from the chromosomes of the yeast cells, and to successfully transfer them to the much simpler E. coli chromosomes...