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Anyone who doubts that the pace of the genetic revolution has accelerated mightily need only consider last week's news about colon cancer. It was just last May that a team of researchers led by Dr. Bert Vogelstein at Johns Hopkins University in Baltimore announced conclusive evidence that a genetic defect causes a hereditary form of colon cancer, accounting for as many as 22,000 cases in the U.S. every year. The next step was to pinpoint the malfunctioning gene, which lurked somewhere on chromosome 2. Back in the 1980s, that search might have taken three years or more. Instead...

Author: /time Magazine | Title: Catching a Rogue Gene | 12/13/1993 | See Source »

According to Medical School Assistant Professor of Medicine Dr. Judy E. Garber, director of the cancer risk and prevention program at the Dana Farber Cancer Institute, screening will begin with tests for the gene in the healthy relatives of colon cancer patients...

Author: By Virginia A. Triant, | Title: Colon Cancer Gene Discovered | 12/7/1993 | See Source »

...discovery has received particular attention in scientific circles because it was unanticipated--and came about as a result of basic genetic research not directed specifically at colon cancer...

Author: By Virginia A. Triant, | Title: Colon Cancer Gene Discovered | 12/7/1993 | See Source »

...hunch was confirmed with the publication this summer of several scientific journal articles. According to the articles, tumor cells from patients with the inherited form of colon cancer bore a base pair sequence similar to that carried by the yeast mutants he was studying...

Author: By Virginia A. Triant, | Title: Colon Cancer Gene Discovered | 12/7/1993 | See Source »

Intrigued, Kolodner's research group sequenced the mutations and found that they lay in the region of chromosome 2 known to be involved in colon cancer...

Author: By Virginia A. Triant, | Title: Colon Cancer Gene Discovered | 12/7/1993 | See Source »

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