Word: colonizers
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When Mr. and Mrs. George Fry set sail from England and arrived in Weymouth, Mass., in the 1630s, they brought to America more than just luggage and four kids. They also brought the original gene mutation that leads to a hereditary form of colon cancer - and has resulted in thousands of people in the United States today who are at higher risk of developing the disease...
...people with AFAP - who account for less than 1% of the 153,000 colorectal cancer cases in the U.S. every year - have a greater than two-in-three risk of developing cancer, compared with a one-in-24 chance in the general population. People with AFAP can begin develop colon polyps by their late teens (about 50% develop polyps in teenhood; others, later in life), and people with particularly severe cases are often advised to undergo a colectomy. Though colon cancer typically shows up in people over 50, in the Fry family, it has been observed as early...
...genetic mutation (according to the lineage, the other 6,000 members of the clan are not believed to have inherited the mutation), who accounted for 0.15% of all colorectal cancers reported in the state from 1966 to 1995. Based on that percentage, researchers expected to see eight cases of colon cancer from this family in the past 10 years. But because of early medical intervention after the founder mutation was identified in 1993, only one colon cancer diagnosis was made...
...since led to six FDA-approved anticancer drugs that weaken tumors by blocking their blood supply. "The idea was met with skepticism and ridicule back then, but he doggedly persisted in proving his ideas," says Li. "He lived long enough to see his idea transformed into new treatments for colon cancer, lung cancer, kidney cancer, liver cancer and multiple myeloma...
...very amazed at how well the Harvard students have been able to blend in with the Madison Park students,” Colon said. “Sometimes it is hard to tell who the tutors are and who the students...