Word: colons
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Dates: during 1980-1989
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...restricted to AIDS research, however. Hunt cites another project with implications for the care of delicate animals in captivity--an effort to determine why captive cotton-top tamarinds--an endangered species--often suffer from ulcerative colitis, a disease that can lead to cancer of the colon. The center has received an NIH grant to study this tendency in about 80 of the monkeys. He says it is not known whether this condition exists in the wild...
When Ronald Reagan's doctors announced two years ago that the President suffered from colon cancer, the world also learned that his brother Neil had received the same diagnosis. That apparently incidental detail did not surprise cancer researchers. They have long known that family members can share a genetic predisposition to the disease, but the exact mechanism was a mystery. Last week scientists in Britain and Israel reported in the journal Nature that they had discovered that there is a faulty gene that triggers a rare form of colon cancer and found its general location. The discovery, said Sir Walter...
...accounts for less than 1% of the 170,000 new cases of colorectal cancerdiagnosed in the U.S. and Britain each year. That led Bodmer to ask, "Could the same gene be involved in the normal run of colon cancers?" The researchers analyzed tumors removed from 45 patients with common colorectal cancer. Result: the section of chromosome 5 that contains the FAP gene was missing in more than 25% of the cases. The finding suggested that such cancers occur only after one protective gene is lost and the other is inactivated. Says Gastroenterologist Sidney Winawer, of the Memorial Sloan-Kettering Cancer...
Should researchers pinpoint that genetic defect, the next step will be to develop a simple diagnostic test. Doctors now recommend that everyone over 50 periodically undergo routine, if unpleasant, examinations with a proctosigmoidoscope, a hollow, lighted tube that is inserted in the colon to look for signs of cancer. A blood test that could alert people that they carried a greater risk of developing colorectal cancer might motivate them to seek frequent checkups...
Cotton himself was born 51 years ago in Colon, at the northern end of the 51-mile-long canal. "Born and raised here, right alongside the canal, and so were my kids," he says. "It is tough to say goodbye when you are fourth generation...