Word: colons
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Floyd Nichols was indomitable. He was only 19 when he was found to have a rare, lethal form of cancer that required the removal of his colon. But the young Chicagoan finished college, in spite of the additional burden of dyslexia, and became a successful computer salesman before starting his own mainframe business. By his mid-30s, he sold it off to begin what his family and friends thought would be a leisurely early retirement. When he told them he would cure cancer instead, they just laughed. How could a layman--even a wealthy one--do what had stumped even...
...scientists. Eventually he talked to Dr. Randall Burt, now the chief of gastroenterology at the University of Utah. Coincidentally, Burt had just heard University of Colorado surgeon William Waddell tell a scientific meeting that he had seen an aspirin-like arthritis drug called sulindac (Merck) almost miraculously melt away colon polyps. The finding was anecdotal, observed in only a few patients, but it was just what Nichols wanted to hear...
Still, Nichols wanted to know how FGN-1 worked. Until then, colon cancer was thought to be a disease of uncontrolled growth. Nichols' scientists suspected instead that the problem was uncontrolled death. Cells lining the intestines usually live only 72 hours. But while cells are born at the usual rate in FAP patients, some fail to self-destruct, producing an excess. Johns Hopkins' Giardiello eventually showed that drugs like sulindac work by restoring the natural process of cell death in the colon. Precisely how it does that, however, remains unknown...
Last year Cell Pathways began tests on children. The first child to be enrolled in the study was Eric Nichols, 11, who had been found to have his father's disease. Other studies are showing that related drugs may be effective against a broad range of cancers, including colon cancer, the No. 2 cause of cancer deaths...
Senior tailback Brian Tuma had a career day for the Leopards with 123 yards on 23 carries and a one-yard TD run that sealed the victory. Lafayette had taken the lead less than a minute into the game when free safety Angel Colon intercepted Brian Mann's pass and returned it 43 yards for a 7-0 lead. Mann finished with 256 yards passing but also three interceptions...