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...amount of microbes that reside in the intestines. In the current study, scientists found that in TLR5-deficient animals, the total percentage of 150 species of bacteria in the gut was three to four times higher than in normal mice, while 125 other types of bacteria were less common. "We don't have a sense of which is more important yet - that some of those species are missing, or that some are in greater abundance," he says. The net effect, however, is that in the absence of TLR5, the community of microbes changes and, as Gewirtz says, "when the intestinal...

Author: /time Magazine | Title: A Hidden Trigger of Obesity: Intestinal Bugs | 3/5/2010 | See Source »

...What was unique in our approach was that we were interested in alterations across different cancer types,” said HMS student Craig H. Mermel. “We want to stop looking at brain cancer or lung cancer but instead diagnose cancer by mutations common to the disease...

Author: By KATHERINE M. AGARD, CONTRIBUTING WRITER | Title: Altering Cancer Diagnosis | 3/5/2010 | See Source »

Although the exact role of SCNAs is still unclear, the researchers found that a large number of SCNAs identified in individual cancer types are present over several cancers of different origin. The common SCNAs may act as important markers in the diagnosis and treatment of cancer, according to Rameen Beroukhim, a clinical fellow in oncology at Harvard-affiliate Dana-Farber Cancer Institute...

Author: By KATHERINE M. AGARD, CONTRIBUTING WRITER | Title: Altering Cancer Diagnosis | 3/5/2010 | See Source »

...their findings has already prompted funding from the National Institutes of Health, the Doris Duke Charitable Foundation, the Sarah Thomas Monopoli Lung Cancer Research Fund, the Lucas Foundation, and several drug companies—most notably Novartis—in the hope of developing drugs that may specifically target common genetic alterations across cancer types...

Author: By KATHERINE M. AGARD, CONTRIBUTING WRITER | Title: Altering Cancer Diagnosis | 3/5/2010 | See Source »

McDonald’s golden arches are a common sight in these neighborhoods, and Bennet says thatthe availability of cheap, fried foods likely hinders efforts to lead healthier lives...

Author: By Barbara B. Depena, CRIMSON STAFF WRITER | Title: Harvard Medical School's Family Van Short on Funds | 3/5/2010 | See Source »

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