Word: compounded
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...rely when EGFR is blocked. But when Mendelsohn applied for his first grant from the National Cancer Institute in 1983, he was rejected. "Nobody thought it would work," he says. The following year he turned to philanthropic sources for research dollars. Last year he wowed colleagues with a compound called IMC-C225, which proved effective in treating colon tumors in a small number of patients...
...that keep EGF from doing its job. Glivec, which reversed Reiter's and Ferber's leukemia so dramatically, is another; so is Tarceva, a drug from OSI Pharmaceuticals in Uniondale, N.Y., which is showing promise against some lung tumors as well as head and neck cancers. Neither of these compounds keeps EGF from docking with cells; instead, each worms its way inside the cells, where it intercepts growth messages percolating in from the surface. Astra Zeneca, headquartered in London, is testing a similar compound, Iressa, against some lung, stomach and prostate cancers...
...more trouble with the law, but it was never signed. Bakley lived in a guest house behind Blake's ramshackle home in Studio City, but even so she was rarely around. A nanny cared for her baby, Rose Lenore Sophia, who lived in Blake's part of the compound. Braun said that Blake's bodyguard had seen a mysterious man outside the residence not long before the murder...
...Fusion inhibitors are the rising stars of the entry inhibitor group. Designed to keep the HIV virus from fusing to the cell wall, fusion inhibitors include compounds called T-20 and T-1249. The first compound, T-20, appears to be at the head of the class, so to speak; researchers report low toxicity among test cases, and relatively mild side effects like soreness and inflammation at the injection site, dizziness and nausea. For the needle-phobic, T-20 may cause a few problems - patients are required to inject themselves twice a day. But for most, even multiple injections...
Lawsuits against the more extreme groups have also taken their toll. Last October, in a case brought by the SPLC, the Aryan Nations white-supremacist group in northern Idaho lost its 20-acre compound near Coeur d'Alene. The Aryans are planning a parade with armed guards through the town this July, but police expect antimilitia protesters to outnumber marchers...