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Rimonabant, the weight-loss compound they developed, is the first drug that manipulates the endocannabinoid system, a network of cells in the brain, the liver and fat tissue that regulates hunger by linking appetite to the body's reward and satisfaction system. Rimonabant reduces food cravings by deactivating the cannabinoid receptors. The drug, to be marketed as Acomplia, is being reviewed by the FDA and will be targeted at those who not only carry excess weight but also harbor unhealthy signs of metabolic disorders such as diabetes and hypertension. In half a dozen clinical trials, the compound helped...

Author: /time Magazine | Title: Medicine: The New Cancer Fighter (And Other Hot Drugs On The Way) | 3/14/2006 | See Source »

...fungal toxin often found in American corn crops, as the likely cause of these infants’ cranial and spinal malformations. The study, conducted on mothers of babies born from the early 1990s to 2000, determined that overexposure to fumonsin inhibits fetal ability to absorb folic acid, a compound known to prevent NTDs. Co-author of the study, Lucina Suarez, who works with the Texas Department of State Health Services, said the implications of NTDs can be fatal. “With anencephaly, the cranium fails to close. This is a very serious defect, as the brain is not enclosed...

Author: By Mallory R. Hellman, CONTRIBUTING WRITER | Title: Tortillas May Cause Fetal Defects | 3/10/2006 | See Source »

...examined the skeleton was led by forensic anthropologist Douglas Owsley of the Smithsonian Institution's National Museum of Natural History. He has worked with thousands of historic and prehistoric skeletons, including those of Jamestown colonists, Plains Indians and Civil War soldiers. He helped identify remains from the Branch Davidian compound in Texas, the 9/11 attack on the Pentagon and mass graves in Croatia...

Author: /time Magazine | Title: Who Were the First Americans? | 3/5/2006 | See Source »

...Love is exciting and fascinating too. Beneath his bland exterior, Paxton subtly shows the pressures of trying to be the breadwinner of a '50s-style household (that would be the 1850s) in the 21st century. And the polygamist compound where Bill grew up keeps pulling him back, Corleone fashion, from the 'burbs, driving the plot in dark, gripping directions. Stanton is perfectly cast as the pious, menacing Roman, who insists on the cut from the second store, although, legally, Roman is an investor in only the first. "There's man's law, and there's God's law," he warns...

Author: /time Magazine | Title: Television: Take My Wives, Please | 3/5/2006 | See Source »

...movie The Cup. Thimphu is the place on which foreign sights are set (even though fewer than 10,000 official tourists still visit every year), not Kathmandu. "You know anything about motorbiking across Bhutan?" a snaggle-toothed hippie asked me as he let me into a Californian hot-springs compound at 1 a.m. on a recent night...

Author: /time Magazine | Title: A Tale of Two Kingdoms | 2/13/2006 | See Source »

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