Word: compounds
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...media attention--by selling their prairie-style clothing online. Available at fldsdress.com the children's apparel, including overalls and "princess dresses," retails for $20 to $70. The group originally launched the site to provide proper outfits for the nearly 400 children taken during the April 3 raid on their compound...
...that Harvard has stopped using calcium chloride to reduce construction-related dust on Allston streets after residents expressed concerns that the compound could potentially harm neighborhood pets and contaminate the water supply, some say the incident was indicative of the University’s failure to keep the community adequately informed of its expansion plans...
...Over the past 60 years, scientists have figured out what works best in what models. The vast majority of animal testing [today] is in rodents, either rats or mice. Rodents, particularly mice, have very short life spans, so you can see how a compound would react in a young animal, then in the same geriatric animal, and then in the next-generation animal, all in a time frame that is reasonable. Then if a product or a compound is determined to be safe in a rodent, another species is used. For example, if it's a neurological compound, oftentimes...
...Animals are surrogates for humans. The basic reason for animal trials is to determine two issues before any new compound is introduced into a human: safety and efficacy, whether a compound is safe for human ingestion and also whether or not a product works for its intended purpose. Really that process begins way before we get to animals. But at some point in the process it is critical to understand how a compound, let's say, a hypertension medication, works in a whole living system. You can't just determine how it works on blood pressure or the heart...
...There is no question that, despite the excellent results that come out of lots of preclinical trials, the human is the ultimate animal model - and sometimes a potential downside to a new compound is not identified until it gets to a human. We often hear you can't give aspirin to cats because it's toxic to them, or you shouldn't give chocolate to dogs. Chocolate, which is very safe in humans, is not safe in dogs. But when you go back and look at how many compounds fail before they ever get to humans, [it's clear] animals...