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...into the function of a protein.” The shape into which a protein folds is determined by the sequence of amino acids that constructs it. The human body has 20 amino acids that can be arranged in any way by the polar forces of water, an abundant compound in cells. Shakhnovich’s model can predict how a certain string of amino acids will fold into a three-dimensional shape with unprecedented accuracy. The team conducted 4,000 simulations that proved to be consistent with experimental results. The biological function of a protein is then decided...

Author: By Nathaniel S. Rakich, CONTRIBUTING WRITER | Title: Chemisty Prof Authors Protein Folding Program | 11/14/2006 | See Source »

...early 1990s, Yale researchers discovered a compound, d4T, that slows the progression of HIV. Yale licensed an exclusive patent for the drug to pharmaceutical giant Bristol-Myers Squibb, which then marketed it under the brand name Zerit...

Author: By Nicholas M. Ciarelli and Daniel J. T. Schuker, CRIMSON STAFF WRITERSS | Title: A New Deal On Lifesaving Drugs | 11/13/2006 | See Source »

Five years later, Yale’s discovery is set to enrich the university once again—and potentially entangle it in another ethical dilemma. Yale announced this past June that it had licensed a new-and-improved version of the d4T compound to Tokyo-based Oncolys BioPharma...

Author: By Nicholas M. Ciarelli and Daniel J. T. Schuker, CRIMSON STAFF WRITERSS | Title: A New Deal On Lifesaving Drugs | 11/13/2006 | See Source »

...secure enough? For the first decade after the ADX was built, the citizens of Florence weren't worried much about the secretive compound, which is only conspicuous when the sun goes down and its banks of light towers glow against the dark horizon. But when Moussaoui, the crazed 9/11 wannabe hijacker, arrived to considerable media fanfare in May 2006, some locals started to feel as if they were living beside a tempting terrorist target. People weren't so much concerned that someone would break out of the fortified ADX, but rather they wondered what would prevent an al-Qaeda squad...

Author: /time Magazine | Title: Inside Bomber Row | 11/5/2006 | See Source »

...according to Sultan, the Pakistani army had been monitoring suspected militant activity at the madrassa for some time. "Yes, the compound was originally a seminary," he says. "But no religious activities were taking place, just militant activities. We gave a warning to the cleric to shut these activities down, but he continued. We can have no tolerance for these kind of activities...

Author: /time Magazine | Title: Pakistan Braces for a Backlash After Taliban Raid | 10/30/2006 | See Source »

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