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...Some drug manufacturers argue that strict tests for safety and effectiveness are unnecessary for over-the-counter medicines. But two Pennsylvania researchers offer a case study to support the argument for such tests. Dr. Karl Rickels and Peter Hesbacher report in the A.M.A. Journal that Compoz, one of the nation's largest-selling nonprescription daytime sedatives, is no more effective than a placebo in relieving "simple nervous tension." The pair base their report on a study of 166 patients with mild to moderate anxiety who were divided into four groups and given Compoz, aspirin, a placebo and the prescription...

Author: /time Magazine | Title: Medicine: Capsules, Jan. 22, 1973 | 1/22/1973 | See Source »

Because they are advertised on television, sold without prescription and consumed by thousands, such over-the-counter sleeping pills as Compoz, Sominex and Sleep-Eze are generally considered safe. But if they are overused, report two Washington, D.C., researchers in the American Journal of Psychiatry, even these drugs can be dangerous, triggering hallucinations and schizophrenic behavior...

Author: /time Magazine | Title: Medicine: Sleeping-Pill Psychosis | 9/4/1972 | See Source »

...organization is reviewing the ads of all member firms to assess their influence on drug abuse. Proprietary drug producers, who last year spent about $118 million in advertising 48 brands of headache, tension and drowsiness remedies, are slowly moving to soften their messages. Jeffrey Martin Inc.. manufacturer of Compoz, "the little blue pill'' sedative, has tacked a caveat to the end of its commercials. "When needed take only as directed; only for the purpose specified." an announcer recites. "Remember: Use, do not abuse...

Author: /time Magazine | Title: Advertising: The Darkening Drug Mood | 8/10/1970 | See Source »

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