Word: conceptive
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According to Fauci, however, the trial was not designed to license the vaccine but to test whether the concept of using the two vaccines in sequence would work. In the latter condition, statisticians say scientists generally consider all data from the complete, original population, since these numbers more accurately reflect what might happen in the real world. In other words, it's a more rigorous analysis of how effective a vaccine might be in a population of people who, realistically, could be exposed to HIV before they finish the full six doses of the vaccine...
...vaccine was not effective? That depends on whom you ask. Some experts argue that the vaccine's effect, if it exists, is so tiny that it's not worth pursuing in a significant way. They also question whether such a large trial can be considered as a proof of concept. "Doing a 16,000-person trial, it can't be a proof of concept at that point," says Dr. David Ho, director of the Aaron Diamond AIDS Research Center in New York City. "Would I invest in it? The answer is no. There are other things that are more likely...
...circumstances surrounding the release of the data should not detract from the potential benefit the results may yet extend to AIDS-vaccine research. The trial was never intended to serve as a demonstration of effectiveness to license a new vaccine, he says. As such, it was a proof-of-concept study that showed it is indeed possible to generate an immune response against HIV - even if only a small...
There are still sitcoms that just aspire to be sitcoms. The highest-rated comedy on TV, Two and a Half Men, is devoutly of the guys-wisecracking-on-a-couch school, and this fall brings plenty of weak, high-concept sitcoms like Hank, which features Kelsey Grammer as a downsized CEO. Even some more-inventive sitcoms are familiar types: FX's It's Always Sunny in Philadelphia, which is like a raucous, lowlife Seinfeld, and ABC's Better Off Ted, a workplace satire with a weird but sincere heart. But one look at Seinfeld's old home, NBC's Thursday...
...green-highway movement is not a no-brainer, according to Dean Greb, a retired Chrysler marketing executive in Saline, Mich., and an EV enthusiast. He lives a half-mile from U.S. 12. "People don't fully understand the concept because they don't see a lot of electric cars and they don't know the trends," says Greb. "It will take funding and time to put in electric charge stations along the route and to promote the concept and to create events that draw people to spend their vacations driving from town to town...