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Researchers discovered the first antidepressants purely by chance in the 1950s. Seeking a treatment for schizophrenia, scientists at the Munsterlingen asylum in Switzerland found that a drug that tweaked the balance of the brain's neurotransmitters - the chemicals that control mood, pain and other sensations - sent patients into bouts of euphoria. For schizophrenics, of course, that only made their condition worse. But researchers soon realized it made their pill perfect for patients with depression. On first trying it in 1955, some patients found themselves newly sociable and energetic and called the drug a "miracle cure." The drug, called imipramine...

Author: /time Magazine | Title: Antidepressants | 1/7/2010 | See Source »

...most that Republicans can hope for is to regain control of the House and pick up a net gain of five seats in the Senate. But in order to achieve this, Republicans must unify their fractured party, and given the spate of conservative primary challenges, from Mark Rubio in Florida to Rand Paul in Kentucky, this will be no easy task. The tea-party movement is also making life difficult for new recruits like Griffith, who after switching parties now faces a tough primary. And the GOP is plagued by cash woes. After spending heavily in the Virginia...

Author: /time Magazine | Title: Senate Retirements Point to Dems' Uphill Election Fight | 1/7/2010 | See Source »

...primary stumbling block to START negotiations has been a disagreement on how to even measure a reduction in nuclear weapons, arms-control experts say. Long-range nuclear missiles and bombers have the capacity to carry multiple, independently targeted weapons. So the question is, should a treaty limit the number of delivery vehicles available to each country, the number of actual warheads or both...

Author: /time Magazine | Title: Obama's Nuclear Arms Pledge Hits Stumbling Block | 1/7/2010 | See Source »

Steve Andreasen, a former director for arms control on the National Security Council, says that Putin's comments were likely a negotiating ploy and that Russia will probably raise its continuing concern about missile defense in later talks. "They are making clear that further reductions in offensive weapons cannot take place divorced from the issue of missile defense - a long-standing Russian position," he says...

Author: /time Magazine | Title: Obama's Nuclear Arms Pledge Hits Stumbling Block | 1/7/2010 | See Source »

...civil war four years later. "You should have seen it," Ghalib Onkumah, a teacher, says, shaking his head and making a face. In the dark days before Saleh took over, there were endless tribal and civil wars, he says. Onkumah, like many Yemenis, is confident that Saleh will maintain control of the country despite the looming threat of state failure. (See why Yemen faces an al-Qaeda threat despite increased...

Author: /time Magazine | Title: In Yemen's Capital, Fearful Talk of War with al-Qaeda | 1/6/2010 | See Source »

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