Word: coproporphyrin
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Dates: during 1960-1969
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...level, in order to determine the ultimate biochemical reasons for its destructive potency. This problem has taken him into many fields. From a commercial laboratory he learned that traces of iron reduce the yield of toxin. He was able to determine that the production of a pink pigment called coproporphyrin was similarly diminished by iron. This discovery in turn led him back to work he had done as a graduate student...
...improved method for measuring the oxidation potentials of hemoglobin. In addition, he had conducted research on cytochromes, iron-containing enzymes which are closely related to hemoglobin. Cytochromes fulfill an important function in the oxidative processes of metabolism in many organisms. Since diphtherial cytochrome is probably a derivative of coproporphyrin, the dual inhibiting effect of iron suggested that the toxin operates by "impersonating" cytochrome...
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