Word: coric
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Dates: during 2000-2009
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...much on hand. Then the signals just keep coming. In the case of the alarm centers in the brain, that means the warning bell just keeps on ringing. "Glutamate has to be taken up quickly because otherwise it becomes toxic to the brain cells," says Vladimir Coric, director of OCD research at Yale University and a leader in studies of the chemical...
...Coric, of Yale, is among the growing group of investigators experimenting with drugs targeting the glutamate problem. The best medication so far, riluzole, was originally developed for Lou Gehrig's disease and works simply by turning down the glutamate spigot, reducing the amount that's available in the brain. In Coric's admittedly small studies and clinical observations, half of about 50 subjects experienced at least a 35% remission, and almost all the rest improved at least a little...