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Nature is not the only lode that drug developers are mining. Linezolid, the novel antibiotic just approved by the FDA, is totally synthetic, and that is a great advantage, believes Pharmacia Corp.'s Dr. Gary Tarpley, who led the team effort that produced the drug. "Because this compound has never been seen by bacteria," he says, "it is extremely unlikely that there is any pre-existing resistance out there." Like tetracycline, linezolid blocks protein synthesis, but it does so much earlier in the cellular cycle. No other antibiotic operates in this fashion, yet another reason to expect resistance to develop...
...treat it, including that old standby streptomycin. New drugs, with different mechanisms of action, would be a great help, particularly if they shortened the present six months' time required for treatment. The linezolid family, for example, appears to hold some promise, as does a compound the Seattle-based PathoGenesis Corp. is investigating...
...Justice, the group showed up again later in the year to disrupt a monetary conference in Melbourne, Australia. Just as graphic as the IMF protests, and hitting closer to home, was the violence associated with the Firestone tire problem. On Aug. 9 the U.S. subsidiary of Japan's Bridgestone Corp. said it was voluntarily recalling 6.5 million Firestone tires owing to safety concerns. If you owned a Ford Explorer, the country's best-selling SUV, you probably had the tires in question. Accidents caused by shreddings had already contributed to at least 46 deaths, an estimate that climbed to more...
...radiation is used instead of surgery. At the present time, it is not a replacement for standard radiation therapy or chemotherapy. Clinical trials are under way, however, that could prove that treatment during surgery using our device may be the only therapy needed. EUAN THOMSON, PRESIDENT AND CEO Photoelectron Corp. Lexington, Mass...
...nine years Johnson hawked the water gun to toymakers. It was going to cost $200,000 to produce 1,000 guns. Finally, at a toy fair in New York City, he was introduced to Al Davis, now the executive vice president at Larimi Corp. "I turned around, and there was the saddest guy I'd ever seen," remembers Davis. "He'd been trying to find somebody who was interested in it. He told me that if we turned him down, he was going to give...