Word: cortisol
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Dates: during 2000-2009
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...probably familiar with the signs of an adrenaline surge (racing pulse, hairs on the neck standing on end), which evolved to help us fight or flee predators and other immediate dangers. And you may have heard of cortisol, another stress hormone, which is produced more slowly than adrenaline and lingers in the bloodstream longer. But did you know that too little cortisol in your bloodstream can be just as bad as too much? Or that tucking into comfort foods, while soothing in the short term, can sabotage your long-term stress response by increasing the number of inflammatory proteins...
What's emerging is a complex picture of the body's response to stress that involves several interrelated pathways. Scientists know the most about cortisol because until now that has been the easiest part to measure. "But when one thing changes, all the others change to some degree," says Bruce McEwen, a neuroendocrinologist at Rockefeller University who has spent decades studying the biology of stress, primarily in animals. So just because you see an imbalance in one area doesn't mean you understand why it is happening. "We're learning that post-traumatic stress disorder (PTSD), burnout, chronic fatigue syndrome...
...GETTING OUT OF BED CAN BE TOUGH ON THE BODY. SEVERAL hours before you wake each morning, a tiny region at the base of your cerebrum called the hypothalamus sends a signal that ultimately alerts your adrenal glands, which sit on top of your kidneys, to start pumping out cortisol, which acts as a wake-up signal. Cortisol levels continue to rise after you become conscious in what is sometimes referred to as the "Oh, s___! It's another day" response. This may help explain why so many heart attacks and strokes occur between...
...Because cortisol is a long-acting hormone, you can dally under the covers a bit without losing any steam. But your brain is already taking steps to protect you from the shock of starting a new day. Rising cortisol levels signal the hypothalamus to stop sounding the alarm. Other parts of the brain chime in, and eventually the adrenal glands ratchet down their cortisol production. In other words, the brain's stress response contains its own off switch...
What happens biochemically, says McGaugh, is that when faced with an emotion-charged situation, such as a threat, our bodies release the stress hormones adrenaline and cortisol. Among other things, these signal the amygdala, a tiny, neuron-rich structure nestled inside the brain's medial temporal lobes, which responds by releasing another hormone, called norepinephrine. Norepinephrine does two important things. First, it kicks the body's autonomic nervous system into overdrive: the heart beats faster, respiration quickens, and the muscles tense in anticipation of a burst of physical exertion...