Word: coumarins
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...another point in the transcript, Wigand alleged that the company introduced into its cigarettes--at "a hundredfold the safety level"--a pipe-tobacco additive, coumarin, that it knew caused liver tumors in laboratory mice. And he described two threatening phone calls, one of which hinted at harm to his two children if he didn't "leave tobacco alone.'' B&W responded to the Daily News article by threatening legal action against CBS News for leaking it. A lawyer for the tobacco company warned that the network would be held responsible for any libel contained in the transcript...
Making matters even more complicated, some drugs increase the potency of enzyme activity. This leads to the bizarre situation in which a heart patient needs more of the anticlotting coumarin drugs if he is also taking barbiturates to allay his anxiety. The "barbies" hasten the breakdown of coumarin, and they have the same effect on some antiepilepsy and antifungal drugs...
...keep a patient on anticoagulants even for such radical operations as amputating a limb, removing a lobe of a lung, or working inside the heart itself to free a hardened mitral valve. In most of the Behrman-Wright cases, the patients took their anticoagulants (usually drugs of the coumarin family) without a break, even on the day of operation...
...from warfare, but from the initials of the Wisconsin Alumni Research Foundation, plus the -arin ending of the coumarin family...
Arteriosclerosis. Far more likely than the problematical spasm as the cause of Eisenhower's stroke is a thrombus. The President has been taking anti-clotting drugs of the coumarin family six days a week ever since his 1955 heart attack. They have been shown to be highly effective in cutting down recurrence of clots caused by embolism (TIME, Feb. 4), but it is not yet certain that they prevent thrombosis...