Word: coumarins
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Dates: during 1960-1969
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Making matters even more complicated, some drugs increase the potency of enzyme activity. This leads to the bizarre situation in which a heart patient needs more of the anticlotting coumarin drugs if he is also taking barbiturates to allay his anxiety. The "barbies" hasten the breakdown of coumarin, and they have the same effect on some antiepilepsy and antifungal drugs...
...keep a patient on anticoagulants even for such radical operations as amputating a limb, removing a lobe of a lung, or working inside the heart itself to free a hardened mitral valve. In most of the Behrman-Wright cases, the patients took their anticoagulants (usually drugs of the coumarin family) without a break, even on the day of operation...