Word: coxes
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...Agnew resigned. Over the next 10 days, Middle East and Persian Gulf nations organized a total oil embargo against the U.S. because of its support for Israel. And on Oct. 20, one day before the embargo took full effect, came the Saturday Night Massacre. Nixon ordered special prosecutor Archibald Cox fired, Attorney General Elliot Richardson resigned in protest, and an honest-to-God constitutional crisis was born...
...1970s, researchers discovered that aspirin reduces that pain and inflammation by lowering prostaglandin levels. It does so by blocking an enzyme called cyclooxygenase, or COX, that's involved in the manufacture of prostaglandins. What scientists didn't know until the early 1990s, however, was that cyclooxygenase comes in at least two versions: COX-1, ultimately responsible for protecting the stomach and making platelets sticky; and COX-2, which triggers pain and inflammation. The obvious goal, at least as far as pain relief is concerned: develop a drug that blocks COX-2 and not COX...
...COX-2 inhibitors may not just control pain; they may also one day prevent some types of cancer. Researchers have learned that malignant cells in the intestines manufacture COX-2 enzymes to accelerate their growth. (That may help explain why consuming fruits and vegetables, which block COX-2 enzymes naturally, seems to protect against colon cancer.) Clinical trials are under way in England to see if superaspirins can prevent colon cancer. Other scientists, meanwhile, have determined that COX-2 inhibitors could conceivably lessen some of the brain damage in Alzheimer's disease...
...there anything superaspirins can't do? Unfortunately, COX-2 inhibitors, unlike aspirin, have little or no effect on heart disease, since it's the COX-1 enzymes that cause blood clotting. But so far, no one knows how to block the COX-1 enzymes in the bloodstream without also affecting the ones that help protect the stomach...
...begin until doctors start writing prescriptions for hundreds of thousands of people. The trouble with Duract, for example, showed up only after patients took the painkiller for several weeks--much longer than most subjects in the clinical trial. Researchers don't expect the same sort of trouble from COX-2 inhibitors. But they won't know for sure until long after the first million arthritis sufferers reach for a bottle...