Word: coxing
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...people on the outside it was a big deal. For people living in the Yard, it was not a big deal,” says Sheila Quinn Cox ’76. “I grew up with two brothers...
...first gesture of conciliation dropped their efforts to stall the nomination of Solicitor General Ted Olson, Bush's more controversial judicial nominations may die in Leahy's Judiciary Committee--or be euthanized before they get there. On Saturday, for example, the New York Times reported that California conservative Chris Cox asked Bush not to nominate him to the federal bench because the confirmation fight would now be too bloody...
...oncologist at Johns Hopkins University, are searching for diagnostics that will pick up other cancers in their preliminary stages. Others are focusing on an even earlier stage, trying to lower the risk of developing cancer to begin with. Here the most exciting work centers on the cycooxygenase inhibitor called COX-2. This pain reliever was originally developed to clamp down on inflammation as aspirin does but without aspirin's tendency to eat through the lining of the stomach...
...turns out that COX-2 inhibitor drugs also have anticancer effects, reducing the number of precancerous polyps in patients with a hereditary form of colon cancer, perhaps through antiangiogenesis. Scientists are currently studying its effect on noninherited colon cancers. And because the receptor for COX-2 is overexpressed on a range of human cancer types, the hope is that COX-2 inhibitors may be useful in preventing a wider range of cancers, including head and neck, bladder, non-small cell lung and breast cancers...
Eventually, the goal is to detect precisely which molecular processes have gone wrong in an individual patient's cancer. Rather than being identified as lung cancer or breast cancer or kidney cancer, tumors will be tagged as EGFR positive, for example, or COX-2 positive. "The dream," says M.D. Anderson's Mendelsohn, "is that if Mrs. Smith gets a breast biopsy, we'll be able to say, 'Here are the four genes that are abnormal in her tumor,' pull open a drawer, pick out the antibodies or small molecules designed against the abnormal products of those genes, and give...