Word: coxing
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...alternative, if the statute is junked, is the existing law allowing the Attorney General to appoint special prosecutors in rare instances; they have marginally less independence but have worked well in the past. Leon Jaworski was the Watergate special prosecutor after Cox. "Archibald Cox got fired, yes, but there was a hue and cry, and Leon Jaworski was appointed almost immediately," says Jim Cole of the A.B.A. task force. "He had all the power he needed and was bulletproof." Besides, few can believe that politics is absent from the process now. Seven of the 11 judges who have served...
Chances are you've had plenty of dealings with those irksome little enzymes cyclooxygenase 1 and cyclooxygenase 2, better known as cox-1 and cox-2. They're what you suppress every time you take an aspirin. Trouble is, aspirin, ibuprofen and other over-the-counter pain killers wreak havoc on the stomach lining--and kill thousands every year through internal bleeding. So last week, an FDA advisory panel gave the green light to Celebrex, the first of a new breed of drugs called cox-2 inhibitors that promise to deliver all the relief of today's pain killers with...
...manufacturer can't just muscle its way into the $5 billion pain-killing industry and not expect resistance. Even before the FDA acted, the cox-1 forces were faxing inflammatory press releases to all takers...
...principle behind the new drugs is that when pain comes calling, it's all cox-2's doing. Cox-1, which wasn't known to be a separate enzyme until 1990, is supposed to be an innocent bystander responsible for "housekeeping" functions--like preventing ulcers. At the FDA meeting, proponents of the old-style pain killers suggested that that theory might be too simplistic. "The whole area of information about cox-1 and -2 is an evolving field," says Dr. Robert Palmer of SmithKline Beecham, which manufactures Relafen, a popular arthritis drug. "There's probably a whole lot of functions...
Tell that to Dr. Philip Needham, father of the cox-2 inhibitor, who calls the white paper Palmer presented to the FDA panel "a predictable effort to protect their drug." If you want evidence that Celebrex works, he says, just ask the 13,000 arthritis patients who took part in its trial. "We're getting letters saying, 'Please don't take us off,'" Needham says. And the side effects? Pretty close to placebo levels...